Abstract
A growing appreciation of the importance of sleep and the impact of sleep disorders on public health has led to a surge in basic sleep research. While humans are the ultimate beneficiaries, the use of animal models is a critical part of this effort. Primary mammalian model systems include rat, mouse, hamster, dog, cat, and monkey. The benefits of small nonmammalian animal models are reflected in the recent increase in studies in zebrafish, Drosophila, and Caenorhabditis elegans . This article will discuss the set up of behavioral monitoring in both a mammalian and nonmammalian model. Even though a major portion of sleep research is behavioral assessment, molecular studies are essential to understand the mechanisms underlying behavior. Thus this article will also discuss the basic set up to carry out molecular and biochemical studies.
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