Setting Characteristics and High Compressive Strength of an Anti-washout, Injectable Calcium Phosphate Cement Combined with Thermosensitive Hydrogel.

Yao Xie,Xiaogang Bao,Shu Cai,Qianqian Li,Guohua Xu,Jia Liu

doi:10.3390/ma13245779

Yao Xie, Xiaogang Bao + Show 4 more

Open Access

https://doi.org/10.3390/ma13245779

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Journal: Materials	Publication Date: Dec 17, 2020
Citations: 10	License type: CC BY 4.0

Affiliation: Tianjin University, Second Military Medical University

Abstract

In this work, a thermosensitive poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) hydrogel was introduced into calcium phosphate cement (CPC) to enhance the anti-washout property of CPC. The effects of the hydrogel on the setting time, injectability, anti-washout property and compressive strength of CPC were thoroughly investigated. The results showed that the hydrogel significantly increased the injectability and anti-washout property of CPC, meanwhile maintained the setting time with an acceptable range. Moreover, the hydrogel improved the initial compressive strength of CPC. The composite cement with 20% v/v hydrogel in the liquid phase showed fine crystals of hydration product, a more compact microstructure and lower porosity compared with control CPC. The analysis of X-ray diffraction (XRD), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) indicated that suitable volume ratio of hydrogel (20% v/v) in the setting liquid of CPC could promote the formation of hydroxyapatite in the early hydration period. The degradation behavior of the cement was characterized by immersion tests in simulated body fluid. The hydrogel had no adverse effect on the degradation rate of CPC over the immersion period of 23 days. This study indicated that incorporating PLGA-PEG-PLGA hydrogel could be a promising strategy to reinforce the handing properties and initial compressive strength of calcium phosphate cement.

Highlights

Calcium phosphate cement (CPC) is generally considered as a promising bone substitution material in the fields of kyphoplasty or vertebroplasty due to its self-setting and biocompatibility [1].CPC always consists of two phases, -solid particles and liquid, which, upon mixture with each other, form a moldable paste to fill the complex bone defect site and undergo a hydration reaction, resulting in a strong material–bone interface [2,3]
As the volume ratio of hydrogel continued to rise to 40% v/v (CPC-40), the relative intensity of carbonate-substituted hydroxyapatite (CHA) and HA
An injectable calcium phosphate cement composite was successfully fabricated by combined with PLGA-PEG-PLGA hydrogel

Summary

Introduction

Calcium phosphate cement (CPC) is generally considered as a promising bone substitution material in the fields of kyphoplasty or vertebroplasty due to its self-setting and biocompatibility [1]. CPC always consists of two phases, -solid particles and liquid, which, upon mixture with each other, form a moldable paste to fill the complex bone defect site and undergo a hydration reaction, resulting in a strong material–bone interface [2,3]. Decreasing the liquid-to-solid (L/P) ratio was useful to improve the anti-washout property. The increase in the anti-washout property is always accompanied by a decline of compressive strength and an extension of setting time [15]. It is extremely urgent and necessary to find a new strategy to balance the setting time, injectability, anti-washout property and compressive strength of CPC

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