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Highlights

  • There is already a large body of evidence demon­strating that mental illness is associated with high rates of physical morbidity and mortality

  • It was estimated that 14.3% of deaths worldwide, that is about 8 million deaths per year, are attributable to mental disorders and it was concluded that more attention should be paid to the more common mental dis­orders, with emphasis on preventing and managing comorbidity with physical conditions

  • Most neuropsychiatric conditions are attributed to multiple gene involvement but how does this gene network operate? Researchers at Imperial College London used a technique called ‘systems genetics’ to unravel how genes work together in epilepsy

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Summary

No health without mental health

There is already a large body of evidence demon­strating that mental illness is associated with high rates of physical morbidity and mortality. Researchers at Imperial College London used a technique called ‘systems genetics’ to unravel how genes work together in epilepsy. They examined brain tissue donated by 129 people and carried out further analyses using laboratory mice and zebra fish. They were able to identify a gene known as Sestrin 3 (SESN3), which had never been linked to epilepsy before but which is involved in coordinating about. Understanding the mechanisms involved in gene regulation in epilepsy could be useful in the management of other brain conditions, such as Alzheimer’s disease and neurodevelopmental disorders.

Chronic undernourishment
Findings
Good night!
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