Abstract
Background/Objectives: To understand the neural mechanisms underlying response to Constraint Induced Movement Therapy (CIMT) compared with Bimanual Training (BIM). Conclusions/Significance: Our results provide direct evidence of neural plasticity for the group who received constraint induced movement therapy (increased cortical excitability of the impaired motor cortex supported by neurovascular changes on fMRI). Both groups made significant improvements with movement efficiency (JTHFT) and bimanual coordination (AHA) however the CIMT group demonstrated a significant improvement in unimanual capacity (MUUL). Our data suggest that upper limb rehabilitation should commence with CIMT followed by bimanual training to maximize neural plasticity. © 2010 The Authors. Journal compilation © 2010 Mac Keith Press Developmental Medicine & Child Neurology
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