Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects

Abstract

Five new sesquiterpenoids, including two linderanes (1–2) and three eudesmanes (3–5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common characteristic in linderane dimers. Compounds 1–5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity.