Sesquiterpenoids and Phenylpropanoids from Pericarps of Illicium oligandrum

Abstract

Four new merrillianin-type sesquiterpenes, oligandrumins A-D (1-4), two new seco-prezizaane-type sesquiterpenes, veranisatins D and E (5 and 6), and a new phenylpropane glycoside, oligandrumin E (7), were isolated from the ethanol extract of pericarps of Illicium oligandrum, together with six known sesquiterpenoids and two phenylpropanoids. Their structures were established on the basis of extensive spectroscopic analyses. The structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction experiments. Anislactone B (13) and the erythro form of anethole glycol (14) were shown to attenuate the damage induced by H(2)O(2) in SH-SY5Y cells.