Sesquiterpene quinones from a Viet Nam sea sponge Spongia Sp.

Abstract

The CHCl3 extract from a Viet Nam sea sponge Spongia species (Order Dictyoceratida) that was collected during the fifth cruise of the RS Akademik Oparin was investigated in a search for antioxidants in marine organisms. The sea sponge (100 g) was extracted with CHCl3. The extract was separated over a column of Sephadex LH-20 using CHCl3:MeOH (3:1) to afford 1 (35 mg), which was active for trapping DPPH radicals (2,2-diphenyl-1-picrylhydrazyl). Inactive compounds 2 (300 mg) and 3 (35 mg) were also isolated. These were readily identified as ilimaquinone [1, 2] and smenospongiarin [3].