Abstract
Seseli L. is an important genus of the Apiaceae family, with a large number of aromatic species. It is used in traditional medicine extensively, but there is quite limited information on their phytochemicals and biological activities. Seseli petraeum M. Bieb. grows in Northern Anatolia, and there are no phytochemical studies on this species. In the present study, we aimed to investigate the effect of the extracts of S. petraeum on A549 lung cancer cell proliferation. For this purpose, the antiproliferative effect was determined via MTT assay, and the extracts obtained from the root of S. petraeum showed a significant inhibitory effect on cell proliferation. The hexane extract of the root exhibited potent inhibition on A549 cancer cell growth at the 24th hour with 3.432 mg/mL IC50 value. The results also showed that the hexane extract had displayed cytotoxic effect through an arrest at the G0/G1 phase of the cell cycle and induced apoptosis as well as DNA damage of A549 cells. Consequently, this study demonstrated the antiproliferative potential of the extracts from S. petraeum, especially hexane extract from the roots. Further studies are required to identify the mechanisms underlying these effects.
Highlights
Aromatic and medicinal plants have attracted attention as a significant source of natural products all over the world (Canter et al 2005, Singh & Singh 2011, Newman & Cragg 2016)
The cells have proceeded with different concentrations of Seseli petraeum extracts between 0.5 to 10 mg/mL for 24 hr, and their cytotoxic effect on A549 human lung cancer cells was evaluated by MTT test (Figure 1)
Our results showed that almost all parts of the Seseli petraeum (SP) had significant effects on the inhibition of cell proliferation, the hexane extract from the root [1]-SPRH was the most potent inhibitor of cell growth with an IC50 value of 3.432 mg/mL (Table II)
Summary
Aromatic and medicinal plants have attracted attention as a significant source of natural products all over the world (Canter et al 2005, Singh & Singh 2011, Newman & Cragg 2016). Apiaceae is known as a wealthy family of flowering plants with their aromatic and medicinal properties. It is a cosmopolitan family, and most of the species grow in Asia comprised of 455 genera and over 3700 species throughout the world, mostly in temperate regions (Crowden et al 1969, Heywood 1979, Davis et al 1988, Baytop 1999, Pimenov & Leonov 2004, Heywood et al 2007, Sayed-Ahmad et al 2017). Seseli species have been widely used in European traditional medicine, exhibiting antibacterial, antifungal, An Acad Bras Cienc (2020) 92(4)
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