Abstract
The study explored the protective effect of sesamin against lipid-induced renal injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were divided into five groups. The control group was fed a standard diet, while the other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia. Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg·day). Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidney tissues were measured. The renal pathological changes and expression levels of collagen type IV (Col-IV) and α-smooth muscle actin (α-SMA) were analyzed. The administration of sesamin improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein-B, oxidized-low-density lipoprotein, and serum creatinine levels in hyperlipidemic rats, while it increased the high-density lipoprotein cholesterol and apolipoprotein-A levels. Sesamin reduced the excretion of 24-h urinary protein and urinary albumin and downregulated α-SMA and Col-IV expression. Moreover, sesamin ameliorated the superoxide dismutase activity and reduced malondialdehyde levels in kidney tissue. Sesamin could mediate lipid metabolism and ameliorate renal injury caused by lipid metabolism disorders in a rat model of hyperlipidemia.
Highlights
Obesity has become a major global health concern worldwide
It is shown the rats belonging to the four groups fed with a high‐fat diet significantly increased their body weight that the rats belonging to the four groups fed with a high-fat diet significantly increased their body compared with the rats in the NC group (p < 0.05)
The body weight of the sesamin weight compared with the rats in the NC group (p < 0.05)
Summary
Obesity has become a major global health concern worldwide It is considered the primary risk factor for developing many chronic disorders such as dyslipidemia, hypertension, and diabetes [1,2]. These conditions may lead to additional complications later, including chronic kidney diseases (CKDs) [3,4]. Studies in animal models have shown that lipids modulated the progression of CKDs and may even be important factors in the pathogenesis of renal tissue injury [8,10].
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