Abstract
ACCUMULATING EVIDENCE indicates that sesame oil, often used as a vehicle for fat soluble hormones, is not an inert substance. Pollia (1) found that sar - comatous rats exhibited serious injury to visceral organs after intraperitoneal injections of sesame oil. Spurr and Kochakian (2) reported that this oil decreased the survival time of adrenalectomizsed rats by an average of 1.6 days. Tobin (3) and Bruce and Tobin (4), on the other hand, found that while sesame oil was toxic to normal rats itprolonged the survival time of adrenalectomiged rats. Clauson(5) re ported that this oil would cause a decrease in the size of the thymus glands of adult male rats and Stein and Allen (6) found that it increased the number of mitoses in the germinal epithelium of the mouse ovary. From these reports it seems clear that sesame oil is not always physiologically inactive and that it may act either as a stimulator or as an inhibitor dependingupon the conditions of the experiment.
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