Serum Zinc Level and Glycemic Status in Newly Diagnosed Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

Abstract

Background: Reduced level of serum zinc has been observed in patients with type 2 diabetes mellitus (T2DM). Objectives: Estimation of serum zinc level and HbA1c in newly detected T2DM. Materials and methods: This cross-sectional study encompassed 100 newly detected non-pregnant T2DM subjects diagnosed on basis of ADA 2015 criteria (n=100; age: 44.74±11.34 years, mean+SD; Sex: 56/44, M/F) from the department of Endocrinology, BSMMU consecutively. Study period was March, 2015 to April, 2016. Blood sample was collected for measurement of zinc and HbA1c. Height, weight, waist circumference, hypertension, dyslipidaemia, ischemic heart disease (IHD), cerebrovascular disease (CVD), retinopathy, neuropathy, nephropathy, serum creatinine were recorded as confounding variables. HbA1c was measured using the NGSP certified Bio-Rad D-10TM Hemoglobin A1C Program while Zinc by using Atomic Absorption Spectrometric Analysis. Result: There was no statistically significant difference for zinc level in gender groups (M vs. F: 0.91±0.02 vs. 0.88±0.02 mg/L, p= 0.580; M±SEM), age groups (age <25 years: 0.89±0.82, 25 – 34 years: 0.90±0.03, 35 – 44 years: 0.90±0.32, 45 – 54 years: 0.91±0.03, and 55 years: 85±0.03 mg/L, M±SEM; F= 0.379, p= 0.823), body mass index (BMI) groups (BMI <25 vs. 25 kg/m2: 0.92±0.02vs. 87±0.02, p= 0.107), socioeconomic groups (low vs. middle vs. high socioeconomic status: 0.90±0.02 vs. 0.91±0.02 vs. 0.86±0.03 mg/L, M±SEM; F= 0.548, p= 0.580) as well as with and without family history of diabetes (0.90±0.01 vs. 0.89±0.02 mg/L, M±SEM; p= 0.705). Also zinc level was statistically similar among glycemic status groups (HbA1c < 6.5% vs. 6.5-9% vs. > 9%: 0.89±0.40 vs. 0.87±0.02 vs. 0.91±0.02 mg/L, F= 0.568, p= 0.569). Comparisons between groups with or without risk factors like: smoking (0.93±0.10 vs. 0.89±0.10 mg/L, p=0.724), hypertension (0.87±0.02 vs. 0.91±0.02 mg/L, p= 0.237), dyslipidemia (0.87±0.02 vs. 0.90±0.02 mg/L, p=0.393) and also co morbidities like: .......