Serum zinc concentration in patients with acute myocardial infarction in percutaneous coronary intervention era.

Toshitaka Okabe,Morio Ono,Wataru Igawa,Tadayuki Yakushiji,Seitaro Ebara,Yuji Oyama,Suguru Shimazu,Myong Hwa Yamamoto,Kennosuke Yamashita,Taro Kimura,Naoei Isomura,Jumpei Saito,Kisaki Amemiya,Masahiko Ochiai,Takehiko Kido,Yoshiaki Taniyama

doi:10.1371/journal.pone.0203074

Toshitaka Okabe, Morio Ono + Show 14 more

Open Access

https://doi.org/10.1371/journal.pone.0203074

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Journal: PloS one	Publication Date: Aug 30, 2018
Citations: 8	License type: CC BY 4.0

Affiliation: Showa University Northern Yokohama Hospital

Abstract

IntroductionThere were few studies that investigated the association between serum zinc concentration and acute myocardial infarction (AMI) in percutaneous coronary intervention era.ObjectiveWe assessed the relationships between serum zinc concentration, complications, and prognosis in AMI patients after primary percutaneous coronary intervention.MethodsWe conducted a single-center, prospective, observational study including 50 patients with AMI. We divided patients into two groups (High-zinc group and Low-zinc group) by median serum zinc concentration and compared two groups about clinical outcomes up to 1 year follow up.ResultsThe mean age of patients was 66.2 ± 11.8 years old. Patients in the Low-zinc group had ST-segment elevation more frequently than those in the High-zinc group (96.0% vs. 72.0%, P = 0.02). All-cause mortality at 1 year was similar in both groups (P (log-rank) = 0.33). However, the lengths of hospital stay and in coronary care unit were longer in patients in the Low-zinc group than in those in the High-zinc group (15.6 ± 9.2 days vs. 11.9 ± 2.9 days, P = 0.06; 3.9 ± 2.8 days vs. 2.3 ± 0.8 days, P = 0.01). Multivariate regression analysis showed that low serum zinc concentration was associated with the use of cardiac or respiratory assist devices (adjusted odds ratio, 17.79; 95% CI 1.123 to 1216.5; P = 0.04).ConclusionsAlthough there was no significance difference in mortality in Low-zinc and High-zinc groups, low serum zinc concentration was associated with longer stay in the coronary care unit, and was one of the independent predictors for the use of cardiac or respiratory assist devices.

Highlights

There were few studies that investigated the association between serum zinc concentration and acute myocardial infarction (AMI) in percutaneous coronary intervention era
Multivariate regression analysis showed that low serum zinc concentration was associated with the use of cardiac or respiratory assist devices
There was no significance difference in mortality in Low-zinc and High-zinc groups, low serum zinc concentration was associated with longer stay in the coronary care unit, and was one of the independent predictors for the use of cardiac or respiratory assist devices

Summary

Methods

We conducted a single-center, prospective, observational study including 50 patients with AMI. We divided patients into two groups (High-zinc group and Low-zinc group) by median serum zinc concentration and compared two groups about clinical outcomes up to 1 year follow up. Between March 2015 and September 2016, we conducted a single-center open-label prospective observational study. We enrolled AMI patients within 24 hours of symptom onset who underwent primary PCI in Showa University Northern Yokohama Hospital. Patients 20 years of age and older were eligible after successful primary PCI if they provided written informed consent. The study protocol was approved by the Institutional Review Board of Showa University Northern Yokohama Hospital, and complied with the Declaration of Helsinki. Myocardial infarction was defined as symptoms of cardiac ischemia and a troponin level above the 99th centile. The definition required new electrocardiographic evidence of ST-segment elevation or left bundle branch block, or angiographic evidence of coronary artery occlusion [12, 13]

Results

Discussion

Conclusion