Abstract
The study aims to compare the serum zinc and copper levels in chronic hepatitis B and HBV induced cirrhosis, and whether these parameters can be used as markers of conversion from chronic hepatitis to cirrhosis, and if their supplementation would delay the course of the disease.50 chronic hepatitis B and 80 HBV induced Cirrhosis patients were included in the study. Serum zinc and copper levels were estimated in 1800 UV spectrophotometer.Statistically significant decrease in serum zinc levels and a statistically significant increase in serum copper levels were observed in cirrhosis when compared to chronic hepatitis B (P <0.001). Decreased serum zinc and increased serum copper levels indicate the conversion of chronic hepatitis B to cirrhosis. Supplementation of zinc and reduction of copper intake will delay the progression of chronic hepatitis B to cirrhosis and improve survival.
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