Abstract
Introduction Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. Methods and Materials 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). Results Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57. Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. Conclusion Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.
Highlights
Oral lichen planus (OLP) is a chronic mucocutaneous disease
Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; the difference was not significant
Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups
Summary
Oral lichen planus (OLP) is a chronic mucocutaneous disease It is mainly an immune system-related disorder. Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; the difference was not significant. Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. Oral manifestations of lichen planus include reticular, papular, erythematous, plaque-like, ulcerative, and bullous-type lesions [3,4,5] It usually happens in the 4-5th decades of life and female : male ratio is approximately 3 : 2 [6,7,8]. It has been suggested that vitamins and micronutrient deficiencies are effective in initiating or exacerbating the disease [13,14,15,16,17]
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