Abstract
BackgroundAdipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. Vaspin is a novel adipocyte with insulin sensitizing effects. In this study, we planned to estimate serum vaspin concentrations as related to glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM).MethodsA total of 230 elderly patients with T2DM were evaluated. These patients were divided into two groups: patients without complications (T2DM group, n = 110), and patients with macrovascular complications (T2DM + MC group, n = 120). In addition, 60 healthy elderly subjects were enrolled and assigned into the control group (NC group). Relevant parameters were matched for age and gender ratio. Serum vaspin concentrations were measured by Enzyme-linked immunosorbent assay (ELISA). Anthropometric measurements, plasma glucose and HbA1C levels, insulin concentration, liver and kidney functions, and lipid profile were measured for each participant.ResultsSerum vaspin concentrations were significantly higher in the T2DM group than in the T2DM + MC group (F = 13.122, P < 0.01). These concentrations were also significantly higher among females, compared to males (T = 3.567, P < 0.05). Logistic regression analysis revealed that serum vaspin concentration, systolic blood pressure, HDL-C and T2DM duration were independent influencing factors for diabetic macrovascular complications.ConclusionSerum vaspin may be considered as a potential marker to assess the status of elderly patients with T2DM and the risk of developing serious macrovascular complications. Further prospective studies are warranted.Trial registrationChiCTR-OPC-14005698, retrospectively registered on 20 Dec. 2014.
Highlights
Adipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis
We aimed to evaluate the association between serum vaspin concentrations, glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM)
With macrovascular disease as the dependent variable, and gender, age, duration of diabetes, Body mass index (BMI), waist-hip ratio (WHR), systolic blood pressure (SBP), vaspin, hsCRP, TG, total cholesterol (TC), Low density lipoprotein (LDL-C), High-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG), Fasting insulin (FINS), Homeostasis model assessment of insulin resistance (HOMA-IR) and Glycosylated hemoglobin (HbA1C) as independent variables, the analysis revealed a significant positive association between the presence of macrovascular disease and SBP and the duration of diabetes and HOMA-IR (P = 0.032, 0.045, 0.016, respectively), and a significant inverse association between the presence of macrovascular disease and HDL-C (P = 0.034) and serum vaspin concentration (P = 0.024) (Table 4)
Summary
An endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. We planned to estimate serum vaspin concentrations as related to glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM). The latest epidemiological study shows that China has a higher prevalence rate, compared to the United States [2]. The prevalence of type-2 diabetes mellitus (T2DM) in a ≥ 18-year-old and ≥60-year-old Chinese population is 9.7% and 19.6%, respectively [3, 4]. Its incidence, severity, disability and mortality rates are higher in elderly patients with T2DM [5]. Adipose tissue is involved in regulating insulin levels, and is associated with T2DM [7]
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