Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma.

Min-Chao Liu,Min-Chao Liu,Liang-Yi Zhou,Ze-Wu Meng,Hai-Jie Hong,Hai-Jie Hong,Yan-Ling Chen,Yan-Ling Chen,Qiang Du,Qiang Du,Lei Jiang,Lei Jiang,Fei-Fei She

doi:10.1007/s13277-015-3316-3

Min-Chao Liu, Min-Chao Liu + Show 11 more

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https://doi.org/10.1007/s13277-015-3316-3

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Journal: Tumor Biology	Publication Date: Mar 24, 2015
Citations: 11	License type: CC BY 4.0

Affiliation: Fujian Medical University, Union Hospital

Abstract

Gallbladder carcinoma (GBC) is the most common cancer of the biliary tract. Lymph node metastasis (LNM) is the major diffusion route of GBC and is a prognosis factor. The aim of study was to assess the potential of the serum VEGF-C and VEGF-D (sVEGF-C/D) levels to predict the presence of LNM and the survival of GBC patients. The preoperative sVEGF-C/D levels of 31 patients with GBC, 10 patients with cholesterol polyps, and 10 healthy volunteers were measured by enzyme-linked immunoadsorbent assay (ELISA). The sVEGF-C/D levels of patients with GBC were significantly higher than those of people with healthy gallbladders (p < 0.001 and p = 0.001, respectively) and cholesterol polyp (p = 0.032 and p = 0.004, respectively). In GBC, the sVEGF-C levels were associated with LNM (p = 0.011), distant metastasis (p = 0.018), and stage (p = 0.045), but the sVEGF-D levels had a significant association with the tumor depth (p = 0.001), LNM (p = 0.001), distant metastasis (p = 0.047), and stage (p = 0.002). The sVEGF-C/D diagnostic values for the presence of GBC were sensitivity of 71.0 and 74.2 % and specificity of 80.0 and 85.0 %, respectively. With respect to the diagnosis of LNM, the diagnostic values of sVEGF-C/D were as follows: sensitivity 81.2 and 87.5 % and specificity 73.3 and 80.0 %, respectively. The mean survival time with high sVEGF-C was significantly shorter than that with low sVEGF-C (p < 0.001), which was also true for low sVEGF-D (p = 0.032). The preoperative sVEGF-C/D levels might be reliable biomarkers for the presence of disease and LNM in patients with GBC. The sVEGF-C/D levels may be prognosis factors that can predict a poor outcome for GBC patients.

Highlights

Gallbladder carcinoma (GBC) is the sixth most common cancer of the gastrointestinal tract and is most common cancer of the biliary tract [1]
The sVEGF-C/D levels in the patient group In GBC patients, the mean sVEGF-C levels and median sVEGF-D levels were significantly higher than the healthy group (7669.58±2012.00 vs 4951.55±1963.48 pg/ml; p
Association between the clinicopathological feature and the sVEGF-C/D levels of GBC (Table 1) The sVEGF-C levels were associated with Lymph node metastasis (LNM), distant metastasis, and stage (p=0.011, p=0.018 and p=0.045, respectively)

Summary

Introduction

Gallbladder carcinoma (GBC) is the sixth most common cancer of the gastrointestinal tract and is most common cancer of the biliary tract [1]. The incidence rates are extraordinarily high in Asia and relatively high in Korea (13.7/100,000). The 5-year survival rate is only 5 %, and the overall mean survival time is 6 months [2]. Radical resection is the most effective and only potentially curative treatment [3, 4]. Because there are few effective diagnostic measures and classical symptoms, most of patients with GBC are treated at late stages of the disease, resulting in a poor overall prognosis [5]. Lymph node metastasis (LNM) is the major diffusion route of GBC. It is an important component of tumor staging and a prognostic factor for GBC. LNM often occurs in the early stage of GBC.

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