Abstract
Background Prior reports pointed out that individuals having bipolar disorder (during manic episodes) and those with major depressive episode might have changes in their serum uric acid (SUA) levels. The aim of the study was to investigate SUA levels in patients with bipolar I (current manic episode) and major depressive disorders (MDDs) compared with healthy controls. Participants and methods A cross-sectional case–control study with consecutive sampling of 90 participants was conducted. Psychiatric assessment for all participants was performed using the Structured Clinical Interview for DSM IV-TR Axis I Disorders, Arabic version (SCID I). Young mania rating scale and Hamilton depression rating scale were introduced to patients with bipolar disorder I and MDD, respectively, to assess the illness severity. Blood samples were obtained through venipuncture after overnight fasting from 10 to 12 h. Results SUA showed significant higher levels in bipolar disorder group (mean=5.95±0.55) than MDD group (mean=3.36±0.66) and controls (mean=4.54±0.65, P=0.00). On the contrary, SUA revealed a statistically significant lower level in MDD group than controls (P=0.00). There is no significant correlation between SUA levels and severity of current manic and depressive symptoms (P=0.44 and 0.80, respectively). Conclusion SUA levels were significantly higher in patients with manic symptoms than in patients with depressive symptoms and controls. There is no significant association of SUA and severity of manic or depressive symptoms.
Published Version
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