Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea.

Abstract

Serum uric acid (SUA) is an oxidative stress-related biomarker of cardiovascular risk. We sought to discover whether or notSUA was related to left ventricular geometry (LVG) and function among individuals with obstructive sleep apnea (OSA). Patients with OSAand healthy controls were assessed for clinical features, echocardiography, polysomnography, and blood biochemical data. Patients withOSA were divided into four groups: normal geometry (NG), concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH). Correlations of SUA with left ventricular (LV) structure and function were examined through Pearson correlation analysis. The risk variables of LVG were investigated using a multivariate logistic regression model. Compared to controls, patientswith OSA had greater SUA levels. The eccentric hypertrophy (EH) and concentric hypertrophy (CH) groups showed substantially greater SUA levels than the normal geometry (NG) and concentric remodeling (CR) groups (p < 0.05). SUA correlated positively with left ventricular mass index (LVMI) and relative wall thickness (RWT) but negatively with the E/A ratio, according to the Pearson correlation analysis. SUA independently affected EH (OR = 1.021, 95%CI = 1.015-1.028, p < 0.001) and CH (OR = 1.034, 95%CI = 1.025-1.043, p < 0.001) in patients withOSAby the multivariate logistic regression model. Patientswith OSA had elevated levels ofSUA, which were seen to be closely linked with abnormal LVG and function. The findingssuggest that SUA may raise the risk of LV structural and functional impairment in patients with OSA.