Abstract
We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycán Hospital. MetS was defined according to Latin American Diabetes Association (ALAD) criteria and IR with surrogate IR markers, triglyceride-to-HDL-C ratio (TG/HDL-C), and triglyceride-to-glucose index (TyG). The association between SUA and MetS and IR was determined using Poisson regression models in a sample of 292 participants with an average age of 46.2 ± 10.6 years. The total prevalence of MetS was 38%, and the individuals with MetS presented mainly alterations in anthropometric parameters (obesity and body fat). Finally, the adjusted regression models showed that women with SUA in the highest tertile increased the prevalence of MetS (PR: 1.71, 95% CI: 1.07–2.74) compared to the lowest tertile of SUA in women, while SUA increased hypertriglyceridemia and IR (TG/HDL-C and TyG) in both sexes. We concluded that SUA is strongly associated with MetS in women, and SUA increases hypertriglyceridemia and IR in both sexes. On the contrary, more research is required regarding the female population.
Highlights
In recent decades, metabolic syndrome (MetS) has increased dramatically and is considered one of the most important risk factors for cardiovascular disease [1]
The work pace of health personnel, bad sleep quality, stress, and anxiety could increase the risk of cardiometabolic disorders such as diabetes, hypertension, insulin resistance (IR), and MetS [17]. We found it appropriate to conduct a study in a Latin population, in a Peruvian hospital, to analyze the association of MetS with Serum uric acid (SUA) and IR stratified by sex in health personnel
We analyzed the data from a total of 292 individuals (202 women and 90 men). e mean age of the participants was 46.2 ± 10.6 years, and workers were in administrative (25.3%), patient contact (66.5%), and general services (8.2%) positions. e largest proportion was nonsmokers (87.7%), had good nutrition (71.6%), had no family history of diabetes mellitus (DM) (65.1%), reported low-moderate alcohol consumption (93.5%), and were physically active (81.5%). e mean concentration of SUA was 3.9 ± 1.0 mg/dL in the general population, 3.49 ± 0.88 mg/dL in women, and 4.70 ± 0.85 mg/dL in men. e characteristics of both MetS and no-MetS groups are presented in Table S2 in Supplementary Materials
Summary
Metabolic syndrome (MetS) has increased dramatically and is considered one of the most important risk factors for cardiovascular disease [1]. Serum uric acid (SUA) is an excretory metabolite produced by the metabolism of the purines [7]. It can be elevated as a result of the low renal filtration rate, overproduction of purine precursors, and diet [8]. SUA regulates proinflammatory pathways in vascular smooth muscle cells and oxidative stress at the mitochondrial level [9]. It is involved in the mechanisms of metabolic dysregulation mediated by excess fructose [10]. Previous studies have reported the association of SUA concentrations and MetS, IR, DM, and other cardiometabolic diseases [11, 12]
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