Abstract
BackgroundSeveral studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown.PurposeWe investigated whether the relationship between serum uric acid (UA) and LV hypertrophy is independent of intact PTH and other calcium-phosphate metabolism-related factors in cardiac patients.Methods and ResultsIn a retrospective study, the association between UA and left ventricular mass index was assessed among 116 male cardiac patients (mean age 65±12 years) who were not taking UA lowering drugs. The median UA value was 5.9 mg/dL. Neither age nor body mass index differed significantly among the UA quartile groups. Patients with higher UA levels were more likely to be taking loop diuretics. UA showed a significant correlation with intact PTH (R = 0.34, P<0.001) but not with other calcium-phosphate metabolism-related factors. Linear regression analysis showed that log-transformed UA showed a significant association with left ventricular mass index, and this relationship was found to be significant exclusively in patients who were not taking loop and/or thiazide diuretics. Multivariate logistic regression analysis showed that log-transformed UA was independently associated with LV hypertrophy with an odds ratio of 2.79 (95% confidence interval 1.48–5.28, P = 0.002 per one standard deviation increase).ConclusionsAmong cardiac patients, serum UA was associated with LV hypertrophy, and this relationship was, at least in part, independent of intact PTH levels, which showed a significant correlation with UA in the same population.
Highlights
Several previous studies have shown that subjects with higher uric acid (UA) levels more frequently have left ventricular (LV) hypertrophy [1,2,3]
Among cardiac patients, serum UA was associated with LV hypertrophy, and this relationship was, at least in part, independent of intact parathyroid hormone (PTH) levels, which showed a significant correlation with UA in the same population
We investigated whether the relationship between serum UA and LV hypertrophy, if present at all, is independent of serum intact PTH, which may be associated with serum UA
Summary
Several previous studies have shown that subjects with higher uric acid (UA) levels more frequently have LV hypertrophy [1,2,3]. The findings that hyperuricemia and gout occurred with increased frequency among patients with hyperparathyroidism [14] and that serum UA was positively associated with serum PTH in community-dwelling older men [14,15] suggest that there is a relationship between serum UA and PTH. Such an association may be further supported by the observations that recombinant PTH may induce hyperuricemia [16] and parathyroidectomy reduces serum uric acid levels [17]. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is known to be associated with cardiac hypertrophy; whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown.
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