Abstract
BackgroundAlthough uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort.MethodsA total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC.ResultsCAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m2 (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.79–1.08, P = 0.426).ConclusionsUA level was significantly associated with CAC in early CKD, but not in advanced CKD.
Highlights
Uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether uric acid (UA) is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known
On multivariate logistic regression analysis, adjusted for age, sex, coronary artery disease, diabetes mellitus, use of lipid-lowering agents, mean blood pressure (BP), waist-hip ratio, estimated glomerual filtration rate (eGFR), calcium, phosphate, LDL-cholesterol, HDL-cholesterol, PTH, and 24-hour urine protein, UA showed no association with CAC > 0
The patients with CAC > 0 had higher UA levels than those with CAC 0, and UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis
Summary
Uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. Han et al BMC Nephrology (2021) 22:247 tools for detecting coronary atherosclerosis and estimating coronary risk assessment with high sensitivity and specificity [6]. This tool is valid in asymptomatic adults [7, 8] and in the CKD population [9]. The coronary artery calcium (CAC) score is used to assess cardiovascular risk in patients with CKD
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