Abstract
BackgroundCardiovascular disease (CVD) is the leading cause of death worldwide. Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; however, the results have not been summarized in a meta-analysis.MethodsA comprehensive search of all related studies until April 2018was performed in MEDLINE/PubMed and Scopus databases DerSimonianand Laird random-effects models were used to combine hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out.ResultsThirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis. Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% CI 1.33–1.58, I2 = 79%). Sub-group analysis showed this relationshipwasstronger in women compared to men. Moreover, there was a significant non-linear association between uric acid levels and the risk of CVD mortality (r = 0.0709, p = 0.001).ConclusionOur analysis indicates a positive dose-response association between SUA and CVD mortality risk.
Highlights
Cardiovascular disease (CVD) is the leading cause of death worldwide
Thirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis
Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% Confidence interval (CI) 1.33–1.58, I2 = 79%)
Summary
Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; the results have not been summarized in a meta-analysis. Cardiovascular diseases (CVD) are the first leading cause of death worldwide [1]. This might be due to an increased incidence of chronic diseases such as obesity, diabetes, hypertension, dyslipidemia, and hyperuricemia [2]. Evidence suggests that increased levels of serum uric acid (SUA) are associated with the development of hypertension, coronary heart disease (CHD), cardiovascular stroke, cerebrovascular accidents (CVA), and cardiovascular disease [3].SUA concentrations can reflect the amount of purine intake from the diet, inborn purine metabolism, changes in UA secretion Many studies have been conducted assessing the relationship between UA and CVD, there is disagreement about this relationship [6]
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