Abstract
Chuang et al. presented a 7-year follow-up study on the effect of uric acid on the occurrence of ischemic heart disease (IHD), adjusted by age, metabolic factors, lifestyles, medication and working type [1]. They used popular variables in the health examination targeting 128,569 subjects. Kim et al. recently overviewed and conducted metaanalysis on this association precisely, and concluded that hyperuricemia may increase the risk of IHD events, independently of traditional IHD risk factors [2]. But sub-analysis stratified by sex presented that the significance of relative risk disappeared in men, and only Chinese cohort kept significance in case of women. On this point, Chuang et al. handled big cohort and I want to make some queries on their analysis.
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