Abstract
Several studies have reported the association between sleep apnea syndrome and insulin resistance. Being overweight is known risk factor both for sleep apnea syndrome and insulin resistance. However, no studies have reported on the association between serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios (a marker of insulin resistance) and sleep apnea syndrome accounting for body mass index (BMI) status. Subjects for the present cross-sectional study consisted of 1,528 men aged 30-69years undergoing pulse oximetry at a sleep disorders clinic for sleep apnea syndrome. Sleep apnea syndrome was diagnosed as a 3% oxygen desaturation index (ODI) of≥15 events/h. Among study participants, 241 men were diagnosed with sleep apnea syndrome. Independent of classical cardiovascular risk factors, TG-HDL was significantly positively associated with sleep apnea syndrome in participants with a BMI<25kg/m2, but not in participants with a BMI≥25kg/m2. The multivariable adjusted odds ratio (OR) and 95% confidence interval (95% CI) of sleep apnea syndrome per Log TG-HDL was 2.03 (95% CI: 1.36-3.03) for a BMI<25kg/m2 and 1.23 (95% CI: 0.89-1.70) for a BMI≥25kg/m2. An independent positive association between TG-HDL levels and risk of sleep apnea syndrome was observed in participants with a BMI of<25kg/m2, but not in participants with a BMI≥25kg/m2. TG-HDL levels could be an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.
Highlights
Numerous studies have reported an independent association between insulin resistance and sleep apnea syndrome [1,2,3,4,5].On the other hand, a high TG-HDL cholesterol ratio (TG-HDL) has been found to indicate insulin resistance in the general population [6].no studies have reported on the association between TG-HDL and sleep apnea syndrome.a previous Japanese study on sleep apnea syndrome reported a significant correlation between apnea index (AI) and body mass index (BMI), with the former being higher in participants with a BMI C25 kg/m2 than in participants with a BMI \25 kg/m2 [7]
No studies have reported on the association between serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios and sleep apnea syndrome accounting for body mass index (BMI) status
We found that participants with a BMI C25 kg/m2 had significantly higher values for fasting blood sugar and TG-HDL than participants with a BMI \25 kg/m2
Summary
Numerous studies have reported an independent association between insulin resistance and sleep apnea syndrome [1,2,3,4,5].On the other hand, a high TG-HDL cholesterol ratio (TG-HDL) has been found to indicate insulin resistance in the general population [6].no studies have reported on the association between TG-HDL and sleep apnea syndrome.a previous Japanese study on sleep apnea syndrome reported a significant correlation between apnea index (AI) and body mass index (BMI), with the former being higher in participants with a BMI C25 kg/m2 than in participants with a BMI \25 kg/m2 [7]. Numerous studies have reported an independent association between insulin resistance and sleep apnea syndrome [1,2,3,4,5]. A high TG-HDL cholesterol ratio (TG-HDL) has been found to indicate insulin resistance in the general population [6]. No studies have reported on the association between TG-HDL and sleep apnea syndrome. A previous Japanese study on sleep apnea syndrome reported a significant correlation between apnea index (AI) and body mass index (BMI), with the former being higher in participants with a BMI C25 kg/m2 than in participants with a BMI \25 kg/m2 [7]. Another study reported a strong association between BMI and insulin resistance [8]. The association between TG-HDL and sleep apnea syndrome should account for BMI status
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