Abstract
Hypochromic microcytic anaemia includes iron deficiency, anaemia of chronic disorders, beta thalassemia trait and sideroblastic anaemia. To rule out the cause of hypochromic microcytic anaemia is a diagnostic difficulty. The conventional laboratory tests used for diagnosis have few disadvantages. Serum transferrin receptor (sTfR) is the most reliable method for assessment of body iron. Eighty four children were included in this study. They were further divided into four groups: iron deficiency anaemia (IDA), anaemia of chronic disorders (ACD), beta thalassemia trait (β TT) and controls. Children withIDAand ACD were diagnosed on the basis of history and serum iron profile. Subjects with β TT had HbA2 > 3.5%. sTfR were performed on all subjects. Level of sTfR in patients withIDAwas 5.79 μg/ml ± 1.3 μg/ml. In patients with anaemia of chronic disorders (ACD), β thalassemia trait and controls mean sTfR were 2.18 μg/ml ± 0.6 μg/ml, 2.1μg/ml ± 0.5 μg/ml and 2.0 μg/ml ± 0.5 μg/ml respectively. These results show level of sTfR was raised in IDA when compared with controls or ACD and β TT (p value
Highlights
Hypochromic microcytic anaemia is characterized by decreased mean corpuscular volume (MCV) and meanHow to cite this paper: Aslam, M., Mohsin, S., Amin, H., Hussain, S., Ahmed, N. and Bhalli, A. (2014) Serum Transferrin Receptors in Children with Hypochromic Microcytic Anaemia
Level of Serum transferrin receptor (sTfR) was increased in patients with iron deficiency anaemia (IDA)
In patients with β thalassemia trait mean ± SD of sTfR was 2.14 μg/ml ± 0.5 μg/ml and its range was 1.19 - 2.95 μg/ml. When it was compared with IDA significant difference was noted (p < 0.001) but no significant difference was observed when compared with controls or anaemia of chronic disorders (ACD) (p > 0.05)
Summary
Hypochromic microcytic anaemia is characterized by decreased mean corpuscular volume (MCV) and meanHow to cite this paper: Aslam, M., Mohsin, S., Amin, H., Hussain, S., Ahmed, N. and Bhalli, A. (2014) Serum Transferrin Receptors in Children with Hypochromic Microcytic Anaemia. Hypochromic microcytic anaemia is characterized by decreased mean corpuscular volume (MCV) and mean. (2014) Serum Transferrin Receptors in Children with Hypochromic Microcytic Anaemia. Causes of hypochromic microcytic anaemia are iron deficiency anaemia (IDA), anaemia of chronic disorders (ACD), beta (β) thalassemia trait and sideroblastic anaemia. Iron deficiency is the most common cause of hypochromic microcytic anaemia in Pakistan [1]-[3]. Severe deficiency is related to lower intelligence quotient (I.Q) [4]. It may impair psychomotor function, which causes mental retardation and decreased capability to learn. It causes behavioral and cognitive delays [5]. Anaemia of chronic disorders is seen in children having chronic inflammation, infection, malignancy or autoimmune disease [8]
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