Abstract
In order to investigate the role of thyrotropin (TSH) in goiter development and maintenance, the serum TSH concentration, the TSH response to thyrotropin-releasing hormone (TRH), and the increase in serum T3 after TRH were measured in 51 normal subjects and in 65 euthyroid patients with idiopathic nontoxic goiter. Fifteen patients had diffuse goiter, 47 multinodular goiter, and 3 an enlarged gland with a single non-functioning nodule. Serum thyrotropin (TSH) concentrations differed significantly in the two groups, the 95% range of the normal subjects was 2.0 μU/ml). There was no correlation between TSH concentrations and nodularity of goiters. Stimulation with TRH was performed in 52 patients and 39 normal subjects. Patients with basal serum TSH values >0.5 (μU/ml had increases in serum TSH after TRH exceeding those of the controls. However, 1/15 patients with diffuse goiter and 10/37 with...
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