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Abstract
High values for serum thyrotropin concentration were found in 12 cases of hypothyroidism during treatment of mano-depressive illness with lithium salts. A number of patients (334 patients) were then analyzed for serum thyrotropin and thyroxine in a pilot screening program for hypothyroidism during lithium therapy. High values for thyrotropin and low for thyroxine were found in two patients. Another six patients had clear, but less pronounced elevation of their serum thyrotropin concentrations; five of them had normal thyroxine concentrations. It is concluded that thyrotropin analysis may be useful to establish a diagnosis of so-called Li+-induced hypothyroidism. Screening of all lithium-treated patients for hypothyroidism by thyrotropin analysis, on the other hand, would hardly be rewarding.
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