Serum thiamin concentration is negatively correlated with lactate levels in survivors of septic shock

Na Costa,Ms Dorna,Sar Paiva,Lam Zornoff,Al Gut,Mf Minicucci,Ps Azevedo

doi:10.1186/cc12671

Abstract

Thiamine deficiency can be present in 20% of patients in the ICU. This deficiency is considered to be an uncommon source of lactic acidosis in septic patients. An elevated serum lactate level is associated with morbidity and mortality [1]. Increased levels of thiamine increase the activity of glutathione peroxidase (GPx), a major component of the cellular antioxidant system [2]. The objective of this study was to determine the influence of serum thiamine concentrations on lactate levels, GPx activity, length of hospital stay, length of ICU stay and ICU mortality in patients with septic shock.

Highlights

Vascular calcification is a regulated process, which associates with coronary artery disease (CAD) and occurs through an increase in transcription factor expression such as RUNX2, MSX2 and alkaline phosphatase (ALP), inducing calcium deposition
The objective of this study was to verify the incidence of delirium through the CAM ICU instrument in ICU patients followed by physiotherapists
There was a low incidence of delirium in ICU patients followed by physiotherapists

Summary

Introduction

Vascular calcification is a regulated process, which associates with coronary artery disease (CAD) and occurs through an increase in transcription factor expression such as RUNX2, MSX2 and alkaline phosphatase (ALP), inducing calcium deposition. The objective of this study was to evaluate the tendency of the plasma concentration and clearance of PCT as biomarkers for prognosis of patients with severe sepsis and septic shock, compared with another early prognosis marker, the number of SIRS criteria at sepsis diagnosis. The objective of this study was to evaluate the serum activity of MMP-2 and MMP-9, length of hospital stay, length of ICU stay and mortality in patients with septic shock. The objective of this study was to determine the influence of serum thiamine concentrations on lactate levels, GPx activity, length of hospital stay, length of ICU stay and ICU mortality in patients with septic shock. Hypothermia at ICU admission was associated with greater severity scores and increased hospital mortality in this sample of surgical patients studied.

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Conclusion