SERUM TESTOSTERONE LEVELS IN CKD AND EFFECT OF ITS REPLACEMENT ON eGFR

Abstract

Background: Testosterone deciency is common and impairs quality of life in patients with chronic kidney disease. However, there are very few studies about whether testosterone replacement therapy can improve quality of life in patients with chronic kidney disease. Therefore, the present study was designed to correlate the testosterone levels with the stages of chronic kidney disease and to observe the effect of testosterone replacement on eGFR. Methods: This is a prospective study, conducted in Moti Lal Nehru Medical College, Prayagraj and Tejas Microdiagnostics, from September 2017 to August 2022. Adult male patients, who were diagnosed with chronic kidney disease, were included while patients with diabetes and patients on maintenance hemodialysis were excluded from the study. Results: We included 100 diagnosed cases of chronic kidney disease however, 25 patients did not follow the study. Out of 75 patients 42.6% patients having serum testosterone level below 300 ng/dl, 42.6% were found to have serum testosterone levels in range of 300-400 ng/dl and 14.6% patients were having level above 400 ng/dl. Improvement in eGFR level of stage 3 and stage 4 were observed statistically signicant (p-value 0.03 & 0.01 respectively). Staging of the disease improved after testosterone supplementation Conclusion: Present study clearly states that supplementation of testosterone in the patients with chronic kidney disease may leads to improvement in eGFR values and improves the staging of disease, consequently the quality of life. Further studies with more number of patients will clear the doubts about clinical benet and adverse outcomes of the therapy.