Abstract
Median serum testosterone concentration of men with alcoholic cirrhosis (n = 216) did not differ significantly from normal controls (n = 51), but serum testosterone concentrations varied by a factor 43.9 in patients compared to 3.2 in controls ( P < .001). Nineteen percent of the patients had serum testosterone concentrations above 30 nmol/L. Serum concentrations of sex-hormone-binding globulin (SHBG) were significantly ( P < .001) raised, and serum concentrations of calculated nonprotein-bound and non-SHBG-bound testosterone were significantly ( P < .001) decreased in patients compared to normal control values. A number of background variables were analyzed with reference to serum testosterone concentrations by means of multiple regression techniques after having divided the patients into groups (A, B, C) with decreasing liver function by a modification of the Child-Turcotte's criteria. The only significant ( P < .01) background variables associated with log serum testosterone concentrations were: group C (β = −0.828), group B (β = −0.222), age (years) (β = −0.012), duration of hospitalization (days) (β = −0.0077), and concentration of SHBG (nmol/L) (β = 0.0044). Neither previous nor recent (within last six months) alcohol consumption influenced serum testosterone concentrations significantly, but about 50% of the patients had abstained from ethanol for two months or more. The same background variables as above were included as significantly ( P < .01) associated with log serum concentrations of calculated nonprotein-bound testosterone and calculated non-SHBG-bound testosterone, except that SHBG was insignificantly associated to any of the two proportions and that testicular volume was significantly ( P < .05) associated with log non-SHBG bound testosterone. Our data indicate that serum testosterone concentrations (total and nonbound) decreased significantly with decreasing liver function in men with alcoholic cirrhosis.
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