Abstract
Background of Study: Besides reproductive and sexual function, testosterone is reported to regulate metabolism, cardiovascular health, body composition, and enhancement cognitive function. Objective: The aim is to determine the impact of type 2 diabetes mellitus (T2DM) on serum testosterone, in a relationship with insulin resistance in men. Materials and Methods: This was a case-control study comprised 63 male type 2 diabetics (T2Ds) and sixty anthropometrically matched nondiabetic controls that fulfilled the inclusion criteria. Type 2 diabetes was diagnosed based on history and the WHO criteria. Results: There was a significantly lowered testosterone (P = 1 × 10-13) in the diabetics compared to the matched controls. A significantly elevated (P Conclusions: In this study, the low testosterone observed is a consequence of T2DM. Testosterone production seems to be impaired by elevated insulin that accompanies insulin resistance. Normalization of testosterone in controlled diabetes points at diabetic control instead of testosterone replacement therapy in the management of hypogonadism in male T2Ds.
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