Serum soluble ICAM-1 and VCAM in patients with allergic bronchial asthma and rhinitis

Abstract

3~ e~ Serum Soluble ICAM-1 and VCAM in Patients With Allergic ,ll~ll Bronchial Asthma and Rhinitis Diana Mihaela Dumitrascu, Daniela Neculoiu, Ligia Chialda, Valeria Dejica, Dora loan Dejica University of Medicine & Pharmacy, Cluj, Romania BACKGROUND:Adhesion molecules such ICAM-1 and VCAM have been show to play important roles in allergic inflammation. The aim of our study was to evaluate the serum soluble levels of ICAM1 and VCAM in pts with allergic bronchial asthma (ABA) and allergic rhinitis (AR) to HDM. MATERIAL AND METHOD: 11 pts with ABA and AR were compare to 10 nonatopic controls (C) match for sex and age. Fasting serum levels of ICAM1 and VCAM were measured by ELISA (R&D Systems). RESULTS: Circulating ICAM-1 was nonsigniflcantly increase in ABA and AR pts (mean value = 271.36 ng/ml vs 258.42 ng/ml in C, p >0,01) and VCAM was significantly increase. There was (595.39 ng/ml vs 459.85 ng/ml, p < 0.01). There was no correlations between serum ICAM-l and VCAM, and also with severity of disease, IgE, eosinophils. CONCLUSIONS: 1. Serum ICAM-I is slightly, not significant, increase inABA and AR. 2. Circulating VCAM is increase inABA and AR. 3. Circulating ICAMI and VCAM show no correlation.