Abstract
Type 2 diabetes mellitus (T2DM) carries an increased risk for depression. Perturbations in polyunsaturated fatty acid (PUFA) metabolism have been observed in depression and T2DM. PUFAs can be converted by cytochrome P450 epoxygenases (CYP450s) into epoxides, which resolve inflammation, and epoxides are metabolized by soluble epoxide hydrolase (sEH) into inactive or cytotoxic diols. Here, we survey these epoxide and diol “oxylipins” in T2DM patients with and without depression.
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