Abstract
Purpose CD89 (FcαRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease. Methods A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immunosuppressant history and healthy subjects. Correlations between serum levels of sCD89-IgA complexes and disease severity were analyzed. Results Serum sCD89-IgA complexes increased with age (P < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (P < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (P < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (Conclusions Serum sCD89-IgA complexes can guide diagnosis of IgAN in patients without immunosuppressant history, but provide limited help in clinicopathologic prediction.
Highlights
IgA nephropathy (IgAN) is the most common primary glomerular disease in the world and is a major cause for endstage renal failure [1]
Recurrence of IgA deposits in renal grafts of IgAN patients [3] is a compelling evidence suggesting that the kidney itself is an innocent bystander and circulating IgA or its related complexes play an important role in the pathogenesis of IgAN [4]
Serum sCD89-IgA complexes may participate in the pathogenesis of IgAN according to animal experiments [7, 8]
Summary
IgA nephropathy (IgAN) is the most common primary glomerular disease in the world and is a major cause for endstage renal failure [1]. One of the characteristics of IgAN is deposition of polymeric IgA1 in the mesangial regions in the kidney [2]. Recurrence of IgA deposits in renal grafts of IgAN patients [3] is a compelling evidence suggesting that the kidney itself is an innocent bystander and circulating IgA or its related complexes play an important role in the pathogenesis of IgAN [4]. Serum sCD89-IgA complexes may participate in the pathogenesis of IgAN according to animal experiments [7, 8]. The application of serum sCD89-IgA complex concentration is undetermined in IgAN. We tried to Disease Markers explore the clinical implication of sCD89-IgA levels in Chinese IgAN patients and healthy subjects
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