Abstract
BackgroundParkinson’s disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids (SCFAs), derived from gut microbiota, are supposed to anticipate PD pathogenesis via the pathway of spinal cord and vagal nerve or the circulatory system. However, the serum concentration of SCFAs in PD patients is poorly known. This study aims to investigate the exact level of SCFAs in PD patients and its correlation with Parkinson’s symptoms.Methods50 PD patients and 50 healthy controls were recruited, and their demographic and clinical characteristics were collected. The serum concentration of SCFAs was detected using a gas chromatography-mass spectrometer. SCFAs were compared between PD and control groups. The correlation between serum SCFAs and Parkinson’s symptoms and the potential effects of medications on the serum SCFAs was analyzed.ResultsSerum propionic acid, butyric acid and caproic acid were lower, while heptanoic acid was higher in PD patients than in control subjects. However, only the serum level of propionic acid was correlated with Unified Parkinson’s Disease Rating Scale (UPDRs) part III score (R = -0.365, P = 0.009), Mini-mental State Examination (MMSE) score (R = -0.416, P = 0.003), and Hamilton Depression Scale (HAMD) score (R = 0.306, P = 0.03). There was no correlation between other serum SCFAs and motor complications. The use of trihexyphenidyl or tizanidine increased the serum concentration of propionic acid.ConclusionsSerum SCFAs are altered in PD patients, and the decrease of serum propionic acid level is correlated with motor symptoms, cognitive ability and non-depressed state. Thus, the gut microbial-derived SCFAs potentially affect Parkinson’s symptoms through the blood circulation. Propionic acid supplementation might ameliorate motor and non-motor symptoms of PD patients, although clinical trials are needed to test this hypothesis.
Highlights
Parkinson’s disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis
The results showed that the serum Short-chain fatty acids (SCFAs) appeared not to be influenced by levodopa administration as correlation between SCFAs and Levodopa-equivalent daily dose (LEDD) was not observed
We further observed that the serum level of propionic acid was decreased and associated with both motor and nonmotor symptoms
Summary
Parkinson’s disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids (SCFAs), derived from gut microbiota, are supposed to anticipate PD pathogenesis via the pathway of spinal cord and vagal nerve or the circulatory system. This study aims to investigate the exact level of SCFAs in PD patients and its correlation with Parkinson’s symptoms. SCFAs have extensive physical effects on cellular energy metabolism, cholesterol biosynthesis, anti-inflammatory, and immune system regulation [11]. It remains debated whether SCFAs modulate the function of central nervous system through interacting with gastrointestinal, vagal nerves and spinal cord or directly acting on brain cells [12, 13]. We aimed to determine the concentration of SCFAs in the serum of PD patients and investigate the relationship between serum SCFAs and Parkinson’s symptoms
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