Serum SHARP1 and uterine artery Doppler for the prediction of preeclampsia

Noppakorn Prakansamut,Vorapong Phupong

doi:10.1038/s41598-019-48727-8

Noppakorn Prakansamut, Vorapong Phupong

Open Access

https://doi.org/10.1038/s41598-019-48727-8

Copy DOI

Journal: Scientific Reports	Publication Date: Aug 22, 2019
Citations: 12	License type: open-access

Affiliation: Chulalongkorn University

Abstract

The aim of this study was to identify the value of serum SHARP1 levels and Doppler of the uterine artery in singleton pregnancy at 11–13+6 weeks for predicting preeclampsia. A prospective observational study was conducted in pregnant women at 11–13+6 weeks of pregnancy who had antenatal care at King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand, between January 2017 and January 2018. Serum SHARP1 measurement and transabdominal Doppler of the uterine artery were performed. The predictive values of these tests were determined. Data were obtained from 405 pregnant women. Thirty-five women had preeclampsia (8.6%), and six of these had early-onset preeclampsia (1.5%). Preeclamptic women had significantly lower serum SHARP1 levels than pregnant women without preeclampsia (3.6 ng/ml vs 4.7 ng/ml, p < 0.01). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of serum SHARP1 levels of less than 3.89 ng/ml for predicting preeclampsia were 77.1%, 72.7%, 21.1% and 97.1%, respectively. For uterine artery Doppler, the sensitivity, specificity, PPV and NPV of the mean pulsatility index (PI) > 95th percentile for predicting preeclampsia were 5.7%, 95.4%, 10.5% and 91.5%, respectively. For the combination of serum SHARP1 levels with a cutoff value of less than 3.89 ng/ml and a mean PI > 95th percentile, the sensitivity, specificity, PPV and NPV were 77.1%, 70.3%, 19.7% and 97.0%, respectively. This study demonstrated that serum SHARP1 is a promising biomarker for predicting preeclampsia in the first trimester.

Highlights

Preeclampsia is a multisystem disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation
Numerous studies have focused on predictive tests for preeclampsia to identify a more effective and accurate test with higher sensitivity and specificity than maternal risk factors alone
This study demonstrated that serum SHARP1 levels in the first trimester were effective for predicting preeclampsia

Summary

Introduction

Preeclampsia is a multisystem disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. This disorder causes serious complications during pregnancy, such as acute renal failure, pulmonary edema and coagulopathy. Preeclampsia is one of the most common causes of maternal morbidity and mortality worldwide[1,2]. The 2015 guidelines of the American College of Obstetricians and Gynecologists[9] recommend only an appropriate medical history to evaluate maternal risk factors as a screening tool to predict preeclampsia, but the detection rate is only 30%10. Numerous studies have focused on predictive tests for preeclampsia to identify a more effective and accurate test with higher sensitivity and specificity than maternal risk factors alone. HIF-1 is expressed when a balance between the oxygen supply and usage in www.nature.com/scientificreports/

Objectives

Methods

Results

Conclusion