Abstract
Purpose: Sestrin2, a metabolic regulator with antioxidant activity, might have some certain predictability for the occurrence and severity of pre-eclampsia (PE). The purpose of this work was to explore the levels of serum Sestrin2 and PlGF in pregnant women with PE and their correlation with the severity index of the disease.Methods:This was a retrospective case-control study of pregnant women with PE who planned to give birth in our hospital from 05/2017 to 05/2019. Pearson correlation was used to analyze Sestrin2 and PlGF levels with PE severity. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of Sestrin2 and PlGF for PE.Results: There were 52 women in the control group, 46 in the mild PE group, and 36 in the severe PE group. As the severity of PE increased, the median levels of Sestrin2 increased (8.1, 9.8, and 11.8 ng/ml), and the levels of PlGF decreased (156, 117, and 67 pg/ml) in the three groups of women (all P<0.05).The levels of Sestrin2 and PlGF were strongly correlated with mean arterial pressure,proteinuria, newborn birth weight and gestational weeks at delivery (all P<0.001). Sestrin2 and PlGF had high efficiency of diagnosing PE (cut-off: 8.90 ng/ml, Area Under Curve [AUC]=0.979; cut-off: 122.50 pg/ml, AUC=0.963). Additionally, Sestrin2 and PlGF showed high value of severity prediction (cut-off: 11.15 ng/ml, AUC=0.857; cut-off: 68.50 pg/ml, AUC=0.837).Conclusion: Sestrin2 and PlGF are correlated with the severity of PE. Both Sestrin2 and PlGF had high value for PE diagnosis and severity prediction.
 Keywords: pre-eclampsia; Sestrin2; placental growth factor; oxidative stress; severity
Highlights
Hypertensive disorder during pregnancy seriously threatens the health of pregnant women and newborns
There are many studies on the relation of PE with placental growth factor (PlGF) [15,16,17], but there are few regarding the association of Sestrin2
The results suggest that Sestrin2 and PlGF are correlated with the severity of PE
Summary
Hypertensive disorder during pregnancy seriously threatens the health of pregnant women and newborns. The incidence of pre-eclampsia (PE) is higher among women with hypertensive disorders, for a prevalence of about 3% among pregnant women [2,3,4,5]. The severity and onset of PE are closely related to the prognosis of pregnant women. PE results in reduced organ perfusion due to vasospasms and activation of the coagulation cascade [6], leading to early placental ischemia and hypoxia [2, 3]. Late placental ischemiareperfusion injury leads to a placental oxidative stress reaction and the release of various inflammatory factors into circulation, triggering a systemic inflammatory reaction and maternal diseases [7]. Sestrin has antioxidant activity [11, 12], suggesting that it might have some certain predictability for the occurrence and severity of PE [13, 14]
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