Abstract
Nowadays, there is growing interest in the possible relationship between selenium metabolism and the aging process (1). Epidemiological studies show that selenium may have a preventive role in some degenerative diseases such as hepatic cirrhosis, cardiovascular diseases, and some types of cancer (2)(3). However, information on the influence of selenium on aging is contradictory, apart from the fact that the process is not yet well understood. We determined the serum concentrations of Se in 93 institutionalized elderly people in Granada (Spain) as a short-term indicator of human selenium status and its correlation with nutrient intake. In addition, taking into account the role of Se in oxidation, in metabolic changes in plasma lipids, and as a component of glutathione peroxidase, we examined other biochemical markers, e.g., total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides. We likewise studied leukocyte numbers in blood, as an indicator of risk of disease through infection, and established their correlation with serum Se concentrations. To quantify serum selenium, we used the hydride generation atomic absorption spectrometry technique previously optimized (4). Daily dietary intake was determined by the 7-day weighed food record, including a day off (5). Unfortunately, …
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