Abstract

AimsResistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.MethodsOne hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD).ResultsSerum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045).ConclusionThe findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.

Highlights

  • Chronic sub-clinical inflammation has been identified as an important mechanism in the pathogenesis of T2DM and associated cardiovascular complications [1]

  • There were no significant differences in age or blood pressure, Body mass index (BMI) or waist circumstance between case controls and coronary heart disease (CHD) patients

  • Metabolic Characteristics Serum resistin was significantly higher in T2DM 22.6(± 4.5)ng/mL and CHD patients 24.2(± 3.6) ng/mL compared with case controls 18.9(± 3.4) ng/mL (p-value

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Summary

Introduction

Chronic sub-clinical inflammation has been identified as an important mechanism in the pathogenesis of T2DM and associated cardiovascular complications [1]. A major risk factor for T2DM and cardiovascular disease, is established as a state of chronic inflammation (page number not for citation purposes). Cardiovascular Diabetology 2005, 4:10 http://www.cardiab.com/content/4/1/10 T2DM CHD. N Age (years) Diabetes duration (years) Systolic BP (mm/Hg) Diastolic BP (mm/Hg) BMI (KG/M2) Waist (cm) Hips (cm) 50 42.5(10.0).

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