Abstract
AimsResistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.MethodsOne hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD).ResultsSerum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045).ConclusionThe findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.
Highlights
Chronic sub-clinical inflammation has been identified as an important mechanism in the pathogenesis of T2DM and associated cardiovascular complications [1]
There were no significant differences in age or blood pressure, Body mass index (BMI) or waist circumstance between case controls and coronary heart disease (CHD) patients
Metabolic Characteristics Serum resistin was significantly higher in T2DM 22.6(± 4.5)ng/mL and CHD patients 24.2(± 3.6) ng/mL compared with case controls 18.9(± 3.4) ng/mL (p-value
Summary
Chronic sub-clinical inflammation has been identified as an important mechanism in the pathogenesis of T2DM and associated cardiovascular complications [1]. A major risk factor for T2DM and cardiovascular disease, is established as a state of chronic inflammation (page number not for citation purposes). Cardiovascular Diabetology 2005, 4:10 http://www.cardiab.com/content/4/1/10 T2DM CHD. N Age (years) Diabetes duration (years) Systolic BP (mm/Hg) Diastolic BP (mm/Hg) BMI (KG/M2) Waist (cm) Hips (cm) 50 42.5(10.0).
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