SERUM PROTEINS IN RHEUMATOID DISEASE

Abstract

Article1 March 1939SERUM PROTEINS IN RHEUMATOID DISEASEC. W. SCULL, Ph.D., T. F. BACH, M.D., F.A.C.P., RALPH PEMBERTON, M.D., F.A.C.P.C. W. SCULL, Ph.D.Search for more papers by this author, T. F. BACH, M.D., F.A.C.P.Search for more papers by this author, RALPH PEMBERTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-9-1463 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONChronic arthritics present a variety of symptoms which involve deviations from normal protein metabolism.1This is graphically evident in gout, one of the smaller groups of rheumatoid disease, which is characterized by the accumulation of urates in articular and other tissues. This local feature is associated with systemic evidence of an abnormal metabolism of nucleo-protein. The absence of this conspicuous feature in the other and larger groups of rheumatoid disease has diverted attention from a consideration of such deviations in protein metabolism as are presented by them. These deviations include both local and systemic features. One large group, namely...Bibliography1. PEMBERTON R: Arthritis and rheumatoid conditions; their nature and treatment, 2nd Ed., 1935, Lea and Febiger, Philadelphia. Google Scholar2. NICHOLSRICHARDSON EHFL: Arthritis deformans, Jr. Med. Res., 1909, xxi, 149. Google Scholar3. SULLIVANHESS MXWC: The cystine content of the finger nails in arthritis, Jr. Bone and Joint Surg., 1934, xvi, 185. Google Scholar4. SCULLPEMBERTON CWR: Unpublished data. Google Scholar5. KLAUDERBROWN JVH: Sulfur content of hair and nails in abnormal states. II. Nails, Arch. Dermat. and Syph., 1935, xxxi, 26. CrossrefGoogle Scholar6. SCULLPEMBERTON CWR: The influence of dietetic and other factors on the swelling of tissues in arthritis, ANN. INT. MED., 1935, viii, 1247. LinkGoogle Scholar7. DAWSONOLMSTEADBOOTS MHMRH: Agglutination reactions in rheumatoid arthritis, Jr. Immunol., 1932, xxiii, 187. DAWSON, M. H., OLMSTEAD, M., and JOST, E. L.: Comparison of agglutinins and precipitins for Streptococcus hemolyticus in rheumatoid arthritic sera, Jr. Immunol., 1934, xxvii, 355. Google Scholar8. MARRACK JR: The chemistry of antigens and antibodies, London Med. Res. Com., Sp. Rep., 194, 1934. Google Scholar9. KAHLMETER G: Über die Bedeutung der Fahraeusschen Senkungsreaktion bei akuten und chronischen Arthritiden, Klin. Wchnschr., 1926, v, 889. CrossrefGoogle Scholar10. FAHRAEUS R: The suspension stability of blood, Physiol. Rev., 1929, ix, 241. CrossrefGoogle Scholar11. DAVIS JS: Protein studies in atrophic (rheumatoid) and hypertrophic arthritis, Jr. Lab. and Clin. Med., 1936, xxi, 478. Google Scholar12. ALRED-BROWNMUNRO GRJM: The plasma protein and non-protein nitrogen and sedimentation rate in chronic rheumatic disorders, Quart. Jr. Med., 1935, iv, 269. Google Scholar13. HAWKBERGEIM PBO: Practical physiological chemistry, 9th Ed., 1929, Blakiston, Philadelphia, p. 399. Google Scholar14. HOWE PE: The function of the plasma proteins, Physiol. Rev., 1925, v, 439. CrossrefGoogle Scholar15. BOYDBERNARD WCH: Quantitative changes in antibodies and globulin fractions in sera of rabbits injected with several antigens, Jr. Immunol., 1937, xxxiii, 111. Google Scholar16. MADDENWINSLOWHOWLANDWHIPPLE SCPMJWGH: Blood plasma protein regeneration as influenced by infection, digestive disturbance, thyroid and food proteins, Jr. Exper. Med., 1937, lxv, 431. CrossrefGoogle Scholar17. ROSE WC: The significance of the amino-acids in nutrition, Harvey Lectures, 1934-35. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication January 27, 1938.From Abington Memorial Hospital and The Graduate School of Medicine, University of Pennsylvania.The expenses of this investigation were defrayed in part by a grant in memory of Alexander B. Coxe. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLE INDAGINI SULLE CONDIZIONI EMOPROTIDO-PLASMATICHE NELLA VALUTAZIONE DEL RISCHIO CARDIOPATIE IN ASSICURAZIONE VITA, CON PARTICOLARE RIGUARDO ALLE CARDIOPATIE REUMATICHEDie pathogenetische Bedeutung der Allergie für Blut- und KnochenmarksschädenNature of collagen diseasesThe serum proteins in rheumatic diseasesTHE SERUM PROTEINS IN RHEUMATOID ARTHRITIS*ALLAN D. WALLIS, M.D.The plasma-protein fractions during the course of the disease in cases of polyarthritis rheumatica.A Study of Certain Blood Tests which reveal Colloidal Abnormalities in Rheumatic ConditionsThe Blood in Arthritis 1 March 1939Volume 12, Issue 9Page: 1463-1472KeywordsGoutGraduate medical educationHospital medicineMemoryProtein metabolismProteinsSerum proteinsUric acid ePublished: 1 December 2008 Issue Published: 1 March 1939 PDF downloadLoading ...