Abstract
SummaryTwelve serum proteins were measured by quantitative immuno‐electrophoresis in 40 patients; 20 normal, uncomplicated pregnancies, and 20 corresponding gravidae with evidence of mild pre‐eclampsia. Results from the two groups were compared and each contrasted with a group of 30 normal non‐pregnant women, aged 16–45 years.α1‐lipoprotein, haptoglobin and haemopexin show no significant variation from normal.α1 antitrypsin, α1 easily precipitable glycoprotein, GC globulin and caeruloplasmin are raised significantly above the normal level (P = 0.001) in both normal pregnancy and pre‐eclampsia.Transferrin is also raised significantly in normal pregnancy (P = 0.01) and in pre‐eclampsia (P = 0.001).α2macroglobulin, β1AC (C13) and β‐lipoprotein are significantly raised in pre‐eclampsia only–α2M (P = 0.01); β1AC (P = 0.001) and βLP (P = 0.01).The only protein to show a significant difference between normal pregnancy and pre‐eclampsia is β1AC which is a little higher in pre‐eclamptic toxaemia (P = 0.5). These results are not affected by pairing the groups according to age, parity and weeks of gestation.
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