Abstract
The polycystic ovary syndrome is an endocrine condition. One of the leading causes of female infertility and the most common disorder among women. The work was being carried out on 100 Iraqi women (50 cases confirmed with PCOS and 50 controls). Between October 2019 and March 2020, blood samples were collected from the Advanced Institute of Infertility Diagnosis and Assisted Reproductive Technology at AL-Nahrain University and a private laboratory. ELISA was used to evaluate the biochemical parameters of preptin, FSH, insulin, LH, and CCL 18 in serum samples from the AFIAS-6 (AFIAS Automated Immunoassay System). The findings of the analysis indicate that, as opposed to the control group, values of prolactin (ng/ml), LH (mIU/ml), Preptin (pg/ml) and CCL 18 (ng/ml) Quite higher in PCOS sickness (p < 0.001) Compared with the patient group, the values of testosterone (ng/ml) and FSH (mIU/ml) was noticeably higher (p <0.05), and PRLR gene expression levels in PCOS patients were significantly increased by 3.6 times. I n summary, the levels of Preptin and CCL18 can be regarded as PCOS markers.
Highlights
One of the most common metabolic diseases is polycystic ovary syndrome (PCOS)
It is assumed that the neuroendocrine characteristic of PCOS is always the rapid pulsation of LH (GnRH),which is conducive to the LH produced by the pituitary over FSH, and leads to an increase in LH concentration, thereby changing the LH: typical PCOS FSH ratio .Follicular growth is impaired when FSH levels are low, while ovarian androgen development is enhanced when LH levels are high 3.CC chemokine ligand 18 is one of the chemokines that is basically expressed in the lungs and has chemotactic properties
When comparing patients and controls, the findings indicate PCOS patients had significantly higher prolactin, LH, insulin, Preptin and CCL 18 (p
Summary
One of the most common metabolic diseases is polycystic ovary syndrome (PCOS). Overall, the prevalence of PCOS ranges from 2.2% to 26%. It is assumed that the neuroendocrine characteristic of PCOS is always the rapid pulsation of LH (GnRH),which is conducive to the LH produced by the pituitary over FSH, and leads to an increase in LH concentration, thereby changing the LH: typical PCOS FSH ratio .Follicular growth is impaired when FSH levels are low, while ovarian androgen development is enhanced when LH levels are high 3.CC chemokine ligand 18 is one of the chemokines that is basically expressed in the lungs and has chemotactic properties. Preptin hormone is a 34-amino-acid protein that correlates to proinsulin-like growth factor II Asp69-Leu[102] and has recently been isolated. This study was aimed to investigate the levels of Preptin and CCL18 as a diagnostic and can be regarded as PCOS markers
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