Serum Procalcitonin in Septic Meningitis

Abstract

To evaluate the role of serum procalcitonin (PCT) in diagnosis of septic meningitis in children and its efficacy in differential diagnosis. The study included 40 children of septic meningitis admitted in pediatric ward with fever, headache, vomiting and seizure, up to 14y of age. The diagnosis of septic meningitis was based on clinical features; physical examination, blood and cerebrospinal fluid (CSF) cytochemical findings, gram's stain and bacterial culture. Fifteen cases of aseptic meningitis admitted during same period were also included in the study, and 15 children with normal CSF were taken as control. Serum PCT was measured by ELISA Kit. Serum PCT level was significantly higher in children with septic meningitis than those with aseptic meningitis or in controls (p < 0.001). In culture and gram's stain positive 7 cases, serum procalcitonin was significantly elevated (24,768.21 ± 6,567.45pg/mL) than aseptic meningitis(14,451.24 ± 4,266.15pg/mL) (p < 0.001). Further its level was found significantly elevated in partially treated septic meningitis as compared to aseptic meningitis cases (p < 0.001). At optimum cut off value of ≥ 5,000pg/mL, based on area under ROC curve, PCT showed sensitivity, specificity, positive predictive value and negative predictive value of 98.5%, 93.5%, 98.6% and 93.3% respectively. Serum PCT with cut off level of 15,000pg/ml showed sensitivity, specificity, PPV and NPV of 92%, 67%, 91.4% and 71.4% respectively for the differentiation of septic from aseptic meningitis. Serum PCT may be used as diagnostic marker for septic meningitis and its differentiation from aseptic meningitis.