Abstract
Background: Intensive care units (ICUs), despite advances in critical care nursing, have frequent issues with early diagnosis and adequate treatment. Recently discovered world-class procalcitonin (PCT), a revolutionary laboratory marker, has been shown to be useful in this regard. The objective is to Comparison of concentrations of serum procalcitonin (PCT) and c-reactive protein (CRP) with a comparable level of organ malfunction during sepsis and evaluation of the interaction between serum PCT and CRP concentrations with different organ malfunction occurrence in sepsis. Design: It is a Hospital-Based Prospective study. Participants and Setting: Fifty people were admitted to the intensive care unit of Gandhi Medical College. Subjects and Methods: The extent of sepsis-related organ impairment was evaluated with the sequential organ failure assessment (SOFA) on day 1. Patients were identified by category 1(0-6), category 2(7-12), group 3(13-18), and group 4(19-24) in 4 separate classes with varying organ impairment seriousness of sepsis. Serum PCT and CRP concentrations have been measured. Results: The majority of the patients belonged to the age groups of 60-69 years (30%) and 50-59 years (22%) Majority of the patients belonged to the Sofa group 1 around 42% followed by sofa group 2 with 38%, sofa group 3 with 16% and the least belonged to the sofa group 4 with 4%. The mean PCT and CRP concentration in those who survived was 14.73 ng/ml and 149.916mg/L respectively and in those who died were 45.76 ng/ml (p-value <0.001) and 183.584 mg/L (p-value 0.172) respectively. The linear correlation between PCT plasma concentrations and the four groups was significantly stronger than with CRP. Conclusion: In SOFA and serum PCT, The level of organ dysfunction and complications in sepsis patients is closely related to serum CRP levels.
Highlights
A Greek phrase-putrid incorporates the name sepsis
Type of Infections seen in sepsis patients with the majority of the patients being diagnosed with Pneumonia around 42% of them followed by Urinary tract infection (UTI) seen in 22% of the patients with sepsis
The mean PCT was more in sequential organ failure assessment (SOFA) group 4 around 87.71 ng/ml and it was least in group 1 around 7.237 ng/ml
Summary
A Greek phrase-putrid incorporates the name sepsis. Air touch and mortality were solely responsible for the putrefaction of a wound when the putrefaction cycle entered the blood (septicemia). PCT is not attributed to systemic bacterial diseases, respiratory illnesses, inflammatory and allergic conditions. It is not presently known if PCT is primarily affected by microbial inflammation of the extent of multiple organ dysfunctions due to systemic inflammatory reactions. Everyone is graded as 0 to 4 with an elevated frequency of impairment Sepsis markers for both C-reactive protein (CRP) and procalcitonin (PCT) are recognized. Subjects and Methods: The extent of sepsis-related organ impairment was evaluated with the sequential organ failure assessment (SOFA) on day 1. Conclusion: In SOFA and serum PCT, The level of organ dysfunction and complications in sepsis patients is closely related to serum CRP levels
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