Abstract
Hexosamine, total protein-bound hexose, and the hexose and tyrosine content of the mucoproteins in serum have been estimated in fifteen normal subjects and forty diabetic patients. Polysaccharides and proteins were also estimated by paper electrophoresis. The diabetic patients were divided into four groups, those without complications, those with retinopathy, those with miscellaneous complications and those with the Kimmelstiel-Wilson syndrome. The concentrations of the serum polysaccharides were considerably elevated in the group of patients with the Kimmelstiel-Wilson syndrome; the patients with retinopathy showed an increase in the concentration of serum hexosamine. Although there was some evidence that the concentration of these substances increased with the severity of the complications, this was not a regular phenomenon because two patients without apparent complications showed very high concentrations of serum polysaccharides. Changes in serum hexosamine seem to be the most sensitive indication of the onset of complications in diabetes, but cannot be regarded as specific.
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