Abstract
It has been suggested that physical activity is an important factor in the prevention and treatment of cardiovascular diseases. Low serum paraoxononase-1 (PON1) activity is with an associated risk of atherosclerotic disease. In this study, we aimed to investigate serum PON1 activity and lipid hydroperoxide (LOOH) levels in adult football players after three days football tournament. Twenty-three adult male football players and 23 sedentary male subjects after three days football tournament were enrolled. Serum paraoxonase, arylesterase activities and LOOH levels were determined. Serum paraoxonase and arylesterase activities were significantly higher in football players than sedentary subjects (all, p<0.05), while LOOH levels were significantly lower (p< 0.05). Serum LOOH levels were inversely correlated with paraoxonase and arylesterase activities (r=-0.552, p<0.001; r=-0.812, p<0.001; respectively) in adult football players. Our data show, for the first time, that physical activity is associated with increased PON1 activity and decreased oxidative stress after three days football tournament. In addition, physical activity for a healthy life is important in increasing serum PON1 activity, and this may play a role in the prevention of atherosclerosis.
Highlights
Oxidative stress is defined as an increase in reactive oxygen species (ROS) production resulting from a deterioration of the balance between oxidants and antioxidants in the body[1]
Serum TG, total cholesterol (TC) and low density lipoprotein (LDL)-C levels were significantly lower in adult football players compared to in sedentary subjects, while the high-density lipoprotein (HDL)-C levels were significantly higher (p
Serum paraoxonase and arylesterase activities were significantly higher in adult football players than in sedentary subjects, while LOOH levels were significantly lower (p
Summary
Oxidative stress is defined as an increase in reactive oxygen species (ROS) production resulting from a deterioration of the balance between oxidants and antioxidants in the body[1]. The major source of ROS is thought to be the mitochondria of active working muscles[2] In this respect, the balance between free radical generation and antioxidant activity plays an important role in the pathogenesis of coronary heart disease. Objectives: In this study, we aimed to investigate serum PON1 activity and lipid hydroperoxide (LOOH) levels in adult football players after three days football tournament. Results: Serum paraoxonase and arylesterase activities were signiûcantly higher in football players than sedentary subjects (all, p
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