Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy

Fevzi Bedi̇r,Engin Şebi̇n,Banu Bedi̇r,Mehmet Sefa Altay,Hüseyin Kocatürk

doi:10.3906/sag-2004-353

Abstract

Background/aimThis study aimed to examine serum paraoxonase 1 and 3 (PON1 and PON3) activities in benign and malignant diseases of the prostate, to determine lipid profile and malondialdehyde (MDA) levels, and to investigate changes in levels following robotic-assisted laparoscopic radical prostatectomy (RALRP).Materials and methodsA total of 137 patients, including a control group, were enrolled in the study and assigned into four groups. Group 1 (n = 33) consisted of patients previously undergoing RALRP with no recurrence, group 2 (n = 36) consisted of patients diagnosed with prostate cancer (PCa) and undergoing RALRP, and group 3 (n = 34) consisted of patients diagnosed with benign prostatic hyperplasia. The control group (n = 34) consisted of healthy individuals. Serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, cholesterol, prostate-specific antigen (PSA), PON1, PON3, and MDA values were measured. In addition, group 2 MDA, PON1, PON3, and PON1/HDL levels were investigated preoperatively and at the first month postoperatively.ResultsSignificant changes were found in PON1, PON3, and MDA levels. PON1 and PON3 levels decreased significantly in patients with PCa, while MDA levels increased. PON1 and PON3 increased postoperatively in the PCa group, while MDA decreased. BPH group PON1, PON3, and MDA levels were higher than those of the control group.ConclusionAn increase in free oxygen radicals in the body or a decrease in endogenous antioxidant enzyme levels can result in malignant and benign diseases of the prostate. Surgical excision of malignant tissue in PCa causes a decrease in oxidative stress.

Highlights

Prostate cancer (PCa) is the most common type of solid cancer in developed countries and the second most common form of cancer, after lung cancer, in men worldwide [1]
Group 1 (n = 33) consisted of patients previously undergoing robotic-assisted laparoscopic radical prostatectomy (RALRP) with no recurrence, group 2 (n = 36) consisted of patients diagnosed with prostate cancer (PCa) and undergoing RALRP, and group 3 (n = 34) consisted of patients diagnosed with benign prostatic hyperplasia
Surgical excision of malignant tissue in PCa causes a decrease in oxidative stress

Summary

Introduction

Prostate cancer (PCa) is the most common type of solid cancer in developed countries and the second most common form of cancer, after lung cancer, in men worldwide [1]. The incidence of PCa increases with age and it is most prevalent after the age of 65 [2]. PCa risk factors include hormonal and genetic factors, black ethnicity, poor socioeconomic status, a fat-rich diet, and infections [3]. Studies have shown that oxidative stress of various endogenous and exogenous origins increases the risk of PCa [4]. Free oxygen radicals (FORs) and lipid peroxidation are implicated in the etiopathogenesis of several diseases [5]. FORs react with such important compounds as lipids, protein, DNA, and carbohydrates to compromise their structures. FORs and other free radicals in biological systems are one of the most important causes of oxidative stress [6]. In addition to DNA damage and associated

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