Abstract
Background Cardiovascular disease is the leading cause of death in chronic kidney disease and hemodialysis population. The mechanisms of vascular damage in this population are not fully explained by traditional cardiovascular risk factor. Osteoprotegerin (OPG) has been shown as an independent predictor of mortality in CKD patients and proposed as a potential biomarker for vascular calcification. Methods A total of 80 subjects (60 hemodialysis patients and 20-age and sex matched healthy control) were studied. Vascular and valvular calcification was measured using plain X-ray and transthoracic echocardiography. Circulating OPG was measured in addition to standard clinical biochemical analysis. Results Osteoprotegerin level showed significant difference between hemodialysis (5.4 ± 2.8 pmol/l) and controls (0.96 ± 0.41 pmol/l) P p = 0.003 and overall valvular calcification with p value Conclusion There is strong positive relationship between osteoprotegerin and both vascular and valvular calcification in hemodialysis patients. This positive correlation may open the gate for routine estimation of this agent as a surrogate marker of cardiovascular calcification in hemodialysis patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
