Abstract
Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Patients with cfPWV > 10 m/s were designated into the AS group. Results: Twenty-two patients (31.4%) were segregated into the AS group. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS. The receiver operating characteristic curve analysis showed that OPN was correlated with AS with an area under the curve of 0.903 (95% CI 0.809–0.961, p < 0.001). Conclusions: For PD patients, the serum OPN level was correlated with cfPWV and could play an important role in the process of AS.
Highlights
Academic Editors: Adriana Albu, Cardiovascular diseases (CVD), which may be caused by traditional risk factors, such as diabetes mellitus (DM) and hypertension (HTN), as well as other specific risk factors, have been reported to be related with the worse prognosis of patients with chronic kidney disease (CKD) [1]
This study showed that patients on peritoneal dialysis (PD) and with high OPN levels had a high risk of developing aortic stiffness (AS)
Inflammation has been known to play a role in the process of vascular calcification, based on reports that high serum C-reactive protein (CRP), old age, and DM are associated with the presence of aortic calcification in patients with CKD and on HD [24,25]
Summary
Academic Editors: Adriana Albu, Cardiovascular diseases (CVD), which may be caused by traditional risk factors, such as diabetes mellitus (DM) and hypertension (HTN), as well as other specific risk factors, have been reported to be related with the worse prognosis of patients with chronic kidney disease (CKD) [1]. Is a well-known noninvasive technique that indicates vascular function, and is a strong predictor of cardiovascular events and mortality, as well as all-cause mortality in patients with CKD and end stage renal disease (ESRD), independent of the traditional CV risk factors [5,7]. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS.
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