Serum omentin–1 levels in overweight and obese people

Abstract

Objective To investigate serum omentin–1 levels in overweight and obese population in Nanjing and the relationship between serum omentin–1 concentration and body mass index(BMI), waist circumference(WC) and adiponectin. Methods Forty–two overweight or obese subjects and fifty–five normal–weight subjects were enrolled, BMI, WC, fasting insulin, fasting blood glucose, lipids, serum omentin–1, adiponectin were measured and waist–to–hip ratio(WHR), insulin resistance index were calculated. All of the statistical analyses were performed using the SPSS 15.0. Results The serum concentration of serum omentin–1(μg/L) and adiponectin(mg/L) were 0.024±0.012 and 7.7±2.4 in normal–weight subjects, 0.016±0.007 and 6.4±3.1 in overweight or obese subjects. The serum omentin–1 and adiponectin levels in the overweight or obese subjects were significantly lower than those of the normal–weight subjects(all P<0.05), and serum omentin–1 concentration was negatively correlated with BMI(r=–0.321, P<0.05), WC(r=–0.312, P<0.05), WHR (r=–0.243, P<0.05), TG(r=–0.220, P<0.05) and positively correlated with adiponectin(r=0.232, P<0.05). Conclusion Serum omentin–1 levels in overweight and obese Nanjing population are significantly lower than those of the normal–weight subjects, and serum omentin–1 is positively correlated with adiponectin, and omentin might be intimately related to obesity, insulin resistance and type 2 diabetes. Key words: Obesity; Overweight; Omentin–1; Adiponectin